The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design. Environmental chemistry letters covers the interfaces of geology, chemistry, physics and biology. Recent advances and outlook for the isosteric replacement of. Central nervous system agents in medicinal chemistry. Letters in organic chemistry is an essential reading for all organic chemists belonging to both. Archive of organic and medicinal chemistry letters. Current topics in medicinal chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. Cyanohydrin as an anchoring group for potent and selective.
Volume 25, issue 11 pages 22512452 1 june 2015 download full issue. Physiological chemistry and physics and medical nmr. The international scientific journal bioorganic and medicinal chemistry letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility mariehelene larrau. Discovery and crystallography of bicyclic arylaminoazines as potent. Many promising drug candidates and pharmaceutical compounds fail due to idiosyncratic adverse drug reactions iadrs, often arising from the formation of reactive metabolites. Dec 26, 2017 bioorganic and medicinal chemistry letters this is an rss file. Cyanohydrin derivatives as enterovirus 71 ev71 3c protease 3cpro inhibitors have been synthesized and assayed for their biochemical and antiviral activities. Rapid synthesis and antimicrobial activity of novel 4oxazolidinone.
Jul 01, 2019 bioorganic and medicinal chemistry letters this is an rss file. Volume 25, issue 16, 15 august 2015, pages 33823389. In press, journal preproof, available online 21 april 2020. A new impact factor for acs chemical neuroscience and. Received 24 august 2015 revised 14 october 2015 accepted 16 october 2015 available online 19 october 2015. Bioorganic and medicinal chemistry letters impact factor, overall. Bioorganic and medicinal chemistry letters this is an rss file. Remarkably high therapeutic effects without joint swelling were obtained in cia mouse models treated with hl23. Identification of n sulfonyltetrahydroquinolines as rorc. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts. You can use it to subscribe to this data in your favourite rss reader or to display this data on your own website or blog. Her3 has not been the subject of smallmolecule inhibitor development. Prototyping kinase inhibitorcytotoxin anticancer mutual prodrugs activated by tumour hypoxia.
Editorial board current topics in medicinal chemistry. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Zhongguo sheng wu hua xue yu fen zi sheng wu xue bao. Articles from organic and medicinal chemistry letters are provided here courtesy of springerverlag. Among the structural alerts responsible, anilines are wellknown to undergo deleterious metabolic processing, yet isosteric replacement strategies remain limited. Download the understanding the publishing process pdf. The journal is essential for every medicinal chemist who. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug. Compared with the reported inhibitors, cyanohydrins 1s,2s,2. The impact factor if 2018 of bioorganic and medicinal chemistry letters is 2.
Received 4 may 2014 revised 1 september 2014 accepted 20 september 2014 available online 28. Articles published here are of high importance to the study of natural and engineered environments. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging. Surprisingly, compound 5 turned out to be a relatively potent histamine h 2 receptor partial agonist k b. Research progress in organic, biological and medicinal chemistry. Bioorganic chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. Articles are in the form of communications reporting experimental or theoretical results of special interest. Receive an update when the latest issues in this journal are published. Including impact factor1 journal of colloid and interface. Organic and medicinal chemistry letters was merged with chemistry central journal in 2015, becoming the organic and medicinal chemistry section. S,5s16 exhibited significantly improved activity and attractive selectivity profiles against other proteases, which were a result of the specific. As a result, compound 1 attenuated cisplatininduced nephrotoxicity in llcpk1 cells and exhibited a signi.